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cap 1 structures  (New England Biolabs)


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    New England Biolabs cap 1 structures
    Cap 1 Structures, supplied by New England Biolabs, used in various techniques. Bioz Stars score: 96/100, based on 606 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cap+1+structure/bio_rxiv__2024__09__24__614636-96-0-18?v=New+England+Biolabs
    Average 96 stars, based on 606 article reviews
    cap 1 structures - by Bioz Stars, 2026-08
    96/100 stars

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    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA <t>vaccines.</t> <t>Cap-1,</t> Cap structure on 5′ end of <t>mRNA:</t> m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.
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    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA <t>vaccines.</t> <t>Cap-1,</t> Cap structure on 5′ end of <t>mRNA:</t> m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.
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    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA <t>vaccines.</t> <t>Cap-1,</t> Cap structure on 5′ end of <t>mRNA:</t> m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.
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    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA <t>vaccines.</t> <t>Cap-1,</t> Cap structure on 5′ end of <t>mRNA:</t> m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.
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    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA <t>vaccines.</t> <t>Cap-1,</t> Cap structure on 5′ end of <t>mRNA:</t> m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.
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    Image Search Results


    Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA vaccines. Cap-1, Cap structure on 5′ end of mRNA: m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.

    Journal: Molecular Therapy. Nucleic Acids

    Article Title: Delivery strategies for RNA-targeting therapeutic nucleic acids and RNA-based vaccines against respiratory RNA viruses: IAV, SARS-CoV-2, RSV

    doi: 10.1016/j.omtn.2025.102572

    Figure Lengend Snippet: Generations of antisense oligonucleotides. (1) The chemical structure of the first, second, and third generations of oligonucleotides, compared to DNA and RNA structures. DNA, deoxyribonucleic acid; RNA, ribonucleic acid; oligonucleotides modifications: PS, phosphorothioate oligonucleotide; PA, phosphoramidate oligonucleotide; MP, methylphosphonate oligonucleotide; 2′-MOE, 2′-O-methoxyethyl RNA; 2′-OMe, 2′-O-methyl RNA; 2′F, 2′-fluoro RNA; LNA, locked nucleic acid; PNA, peptide nucleic acid; PMO, phosphorodiamidate morpholino oligonucleotide. (2) Chemical structure of modifications used in RNA vaccines. Cap-1, Cap structure on 5′ end of mRNA: m7GpppNm, where Nm is a 2′ -methylated nucleotide; m1Ψ, N1-methylpseudouridine.

    Article Snippet: In contrast, mRNA transcripts containing the CAP-1 structure (m7GpppNm, where Nm is a 2′ -methylated nucleotide), present in Moderna’s vaccine, were created by enzymatic action.

    Techniques: Vaccines, Methylation